| Rank | Player | School | Games | YDS PGM | Rush ATT | Rush YDS | Rush AVG | Rush TD |
|---|---|---|---|---|---|---|---|---|
| 1 | Ryan Mathews | Fresno State | 10 | 149.10 | 213 | 1491 | 7.0 | 14 |
| 2 | Donald Buckram | UTEP | 10 | 142.20 | 217 | 1422 | 6.6 | 14 |
| 3 | Toby Gerhart | Stanford | 10 | 139.50 | 262 | 1395 | 5.3 | 19 |
| 4 | Mark Ingram | Alabama | 10 | 129.70 | 194 | 1297 | 6.7 | 10 |
| 5 | Dion Lewis | Pittsburgh | 10 | 129.10 | 224 | 1291 | 5.8 | 13 |
| 6 | Ryan Williams | Virginia Tech | 10 | 123.50 | 212 | 1235 | 5.8 | 11 |
| 7 | Jacquizz Rodgers | Oregon State | 10 | 114.80 | 215 | 1148 | 5.3 | 17 |
| 8 | Ben Tate | Auburn | 11 | 109.91 | 225 | 1209 | 5.4 | 8 |
| 9 | Jonathan Dwyer | Georgia Tech | 11 | 109.36 | 183 | 1203 | 6.6 | 11 |
| 10 | C.J. Spiller | Clemson | 10 | 83.60 | 153 | 836 | 5.5 | 6 |