Professor Alex Lippert

Alex Lippert
*Assistant Professor*	Office:	141 Fondren Science
Department of Chemistry	Phone:	(214) 768-2482
Southern Methodist University	Fax:	(214) 768-4089
PO Box 750314	e-mail:
Dallas, TX 75275-0314
Research Group Site

Education:

Research Interests:

The Lippert lab combines innovative organic chemistry with state-of-the-art imaging techniques. We synthesize biocompatible dyes and MRI contrast agents that are activated by chemical reactions inside of cells, enabling the real-time tracking of biochemical events in living systems. These newly developed probes will provide unique tools to study cellular chemistry important in cancer, cardiovascular disease, and neuronal signaling.

Selected Publications:

Lippert, A. R.; Van De Bittner, G. C.; Chang, C. J. "Boronate Oxidation as a Bioorthogonal Reaction Approach for Studying the Chemistry of Hydrogen Peroxide in Living Systems." Acc. Chem. Res. 2011 , 47, 793.
Lippert, A. R.; New, E. J.; Chang, C. J. "Reaction-Based Fluorescent Probes for the Selective Imaging of Hydrogen Sulfide in Living Cells." J. Am. Chem. Soc. 2011 , 133, 10078. (Highlighted in the October 17 issue of Chemical & Engineering News)
Lippert, A. R.; Keshari, K. R.; Kurhanewicz, J.; Chang, C. J. "A Hydrogen Peroxide Responsive Hyperpolarized 13C MRI Contrast Agent." J. Am. Chem. Soc. 2011 , 133, 3776.
Lippert, A. R.; Naganawa, A.; Keleshian, V. L.; Bode, J. W. "Synthesis of Phototrappable Shapeshifting Molecules for Adaptive Guest Binding." J. Am. Chem. Soc. 2010 , 132, 15790.
Lippert, A. R.; Gschneidtner, T.; Chang, C. J. "Lanthanide-Based Luminescent Probes for Selective Time- Gated Detection of Hydrogen Peroxide in Water and Living Cells." Chem. Commun. 2010 , 46, 7510.
Ju, L.; Lippert, A. R.; Bode, J. W. "Stereoretentive Synthesis and Chemoselective Amide-Forming Ligations of C- Terminal Peptide α-Ketoacids." Org. Biomol. Chem. 2008 , 130, 4253.