Faculty & Research

James A. Waddle, Ph.D. Assistant Professor Ph.D.: Washington University

Office: 337-DLS Tel: 214.768.4734 Fax: 214.768.3955 Email: jwaddle@smu.edu Lab: 318-DLS Tel: 214.768.1706

Research Interests

Genetic Analysis of Intestinal Microvillus Formation, Xenobiotic Drug Detoxification, and the Transcriptional Response to Reduced Insulin Signaling in C. elegans

Selected Publications

MacQueen, A.J., Baggett, JJ, Perumov, N, Bauer, RA, Januszewski, T,Schriefer, L, Waddle, JA. (2005) ACT-5 is an essential C. elegans actin required for intestinal microvilli formation. Mol Biol Cell 16(7):3247-3259

Rogers E, Bishop JD, Waddle JA, Schumacher JM, Lin R. The aurora kinase AIR-2 functions in the release of chromosome cohesion in Caenorhabditis elegans meiosis. (2002) J Cell Biol 157:219-229.

Epstein CB, Waddle JA, Hale IV W, Varshal D, Thornton J, Macatee TL, Garner HR, Butow RA. (2001) Genome-wide responses to mitochondrial dysfunction. Mol. Biol. Cell 12(2):297-308.

Reese, KJ, Dunn, MA, Waddle, JA, Seydoux G. (2000) Asymmetric segregation of PIE-1 in C. elegans is mediated by two complementary mechanisms that act through separate PIE-1 protein domains. Mol. Cell 6(2)445-455.

Support

Sept 2001 – Aug 2007. NIH, NIA. R01-AG1998301, “Longevity & metabolism mediated by a fasting inducible histone”. PI

May 2004 - April 2005 NIH Shared Instrumentation Grant, Zeiss 510 META Laser Scanning confocal microscope, RFA RR-03-002, PI

Sept 1996 - Aug 2001. Burroughs Wellcome Fund Career Award in the Biomedical Sciences. “Generation of markers and methods to study asymmetric cell division in living C. elegans embyros”, PI

Jan 2002 – Aug 2004. Texas Higher Education Coordinating Board, Advanced Technology Proposal, Co-PI with Leon Avery at UTSW. “A test for HERG blockers based on heterologous expression in C. elegans” (Co-PI)

Education

Ph.D. Molecular Genetics, Washington University, 1993